Current Issue : October - December Volume : 2012 Issue Number : 4 Articles : 11 Articles
Natural medicines are the most useful medicaments in this highly modernized society. To combat against various diseases as tuberculosis, antigenic reactions, coughing, asthma and other allergies, nature acts a booster. Among the other plant materials Ligularia, a highly versatile plant genus with eight different species with different isolated chemical entities works as a boon. The main aim of this article to draw an attention towards the cultivation as well as structural isolation and aiming versatile pharmacological properties....
Ninety male broiler chicks (Cobb strain) of day-old age were randomly divided into six groups consisting of fifteen in each group. Group 1 was maintained as basal diet control and group 2 on lead @ 300 ppm in feed throughout 5 wks as toxic control without any treatment. Groups 3 and 4 were maintained respectively on herbal methionine @ 1.4 gm/ kg feed and Mangifera indica @ 0.1% in feed. Groups 5 and 6 were treated with lead + herbal methionine and lead + Mangifera indica, respectively for the 5 wks. The activity of AST and the concentration of serum creatinine (blood) revealed significant (P < 0.05) increase and there were histological alterations in the lead toxic control group. Treatment with herbal remedies in groups 5 and 6 resulted in a marked improvement in all the above parameters as compared to those of lead toxic control. Thus, it is concluded that herbal methionine and Mangifera indica offered protection against lead-induced organ damage in broilers....
In the few decades, there has been exponentially growth in the field of herbal remedies. Newer guidelines for standardization, manufacture, quality control and scientifically rigorous research will be necessary for traditional treatments. This traditional knowledge can serve as the powerful search engine that will greatly facilitate drug discovery. Standardization of herbal formulations is essential in order to assess the quality, purity, safety and efficacy of drugs based on the amounts of their active principles. The aim of the present work is to formulation and evaluation of astringent and anti diarrhoeal churna preoaration.. The churna makes this traditional drug more stable for long term storage and hence, easier to prepare. an Ayurvedic polyherbal formulation used in the treatment of astringent and anti-diaahoeal churna. One marketed stranded drug and three new formulations were used for the study. All the formulations were standardized on the basis of organoleptic characters, physical characteristics and physico-chemical properties. The set parameters were found to be sufficient to evaluate the churna and can be used as reference standards for the quality control/quality assurance purposes. The analysis and quality control of herbal medicines are moving towards an integrative and Comprehensive direction, in order to better address the inherent holistic nature of herbal medicines. It was observed that all ingredients of commercial samples matched exactly with that of authentic standards after performing the standardization as per WHO guideline. The antidiarrheal effect of ethanolic extract of churna revealed a dose dependant inhibition of castor oil induced diarrhea at doses of 200 and 500mg/kg. On comparison of the extract with the negative control, standard, test. Test extract’s effect was further evaluated on intestinal transit and it exhibited dose dependant inhibition of transit motility of charcoal meal....
This study evaluated the flavanoid and terpenoid fractions seperated from the extract of Lepidigathis cristata and Hemidesmus indicus on reducing hyperglycemia and free radical generation in streptozotocin and nicotinamide induced diabetes mellitus. Flavonoid fraction from Lepidigathis cristata and FTF from (Lepidigathis cristata and Hemidesmus indicus ) was orally administered once a day after three days of streptozotocin – nicotinamide induction at 200mg/kg for 28 days and the results showed that blood glucose, serum total cholesterol, triglycerides levels were significantly decreased, and there is no significant changes in the total protein level. Histopathological reports show the significant regeneration of β – cells in pancreas. The result reveals that both the fraction are potent antioxidants and shows the significant result in various biochemical parameters when compared with FF, FTF, showing the significant hypoglycaemic effect in STZ induced diabetes. The biological action of the both the fractions depends on the individual flavonoids and terpenoids present in the respective fractions, the above statement was supported by the HPTLC analysis....
This study investigate the use of microwave assisted extraction (MAE) to improve the extraction efficiency of the classical solvent extraction techniques i.e. soxhlet extraction technique to extract antioxidant activity compounds & phenolic compounds from the leaves of Momordica dioica. The effects of different extraction conditions were determined, i.e. solvent type, preleaching time, particle size, drug solvent ratio, extraction time & number of extraction cycle. The most favorable conditions were obtained by using fine powdered material, extracted with water (D: S 1:30) at microwave power 160 w for 3 min for three extraction cycles. The result obtained using the optimized method compared with soxhlet extraction techniques; the MAE procedure provides low extraction efficiencies and is less labor intensive as compare to soxhlet....
An experimental study was conducted to evaluate the toxic effects of cisplatin with respect to oxidative stress and organ toxicity. A total of 48 female Sprague dawley rats of 3 months old were divided as follows: Group 1 Control diet; Group 2 Control diet + Cisplatin @ 2 mg/kg b.wt i/p once in a week; Group 3-Control diet + Turmeric @ 0.05 ppm b.wt daily by oral gavage needle; Group 4- Cisplatin +Turmeric as per above doses and routes of administration. The CPK was significantly (P < 0.05) increased in group 2. The tissue enzyme assays revealed a significant (P < 0.05) increase in TBARS and protein carbonyls and significant (P < 0.05) decrease of GSH in Group 2 compared to other groups. The ameliorative group 4 showed mild to moderate improvement in all parameters in comparison to group 2. Sections from heart revealed marked interfibrillar congestion, haemorrhages in purkinje fibres, disrupted cardiac muscle fibres and round cell infiltration. The study revealed that cisplatin-induced toxicity is attributed to the induction of reactive oxygen species with subsequent depletion of antioxidant defenses and eventual oxidative stress. Supplementation of turmeric was found beneficial in countering the toxic effects of cisplatin....
The plant C. officinalis belonging to family Asteracea/Compositae, is native to Central Europe and the Mediterranean, it grows readily in sunny locations throughout North America and Europe. There are about 20 species in this genus cultivated by Egypteans, Greeks, Hindus, and Arabs. Calendula grew in European gardens and has been used medicinally since 12th century. Mainly, the flowers were made into extracts, tinctures, balms, salves and applied directly to skin to help heal wounds and to soothe inflamed and damaged skin. In Italian folk medicine Calendula is used as an antipyretic and anti-inflammatory. The reported pharmacological actions of the plant are, angiogenic property having vascular regeneration parameter affirming the said activity, analgesic properties were confirmed in the flower extract of the plant, it was found triterpenoids were mainly responsible to promote anti-inflammatory activity in the plant, due to presence of faradio esters the plant projects anti-oedematous activity, the additional pharmacological activities explored till date are antimicrobial and antibacterial activity, effective treatment in case of breast cancer, antihepatotoxicity activity, genotoxic and antigenotoxic activity, Hepatoprotective and renoprotective activity, antiviral activity, anti-HIV activity, effective in dealing with periodontal infections, ameliorating incidence of myocardial infarction, antioxidant and anti-immunomodulatory activity, effective treatment for acne, prominent anti-gastric ulcer and wound healing property, effective in dealing with bacterial infections in vets. Further studies of having sun protection factor in Calendula officinalis have also been investigated with positive results. The present review is an anthology of the work done on this potential herbal plant, having prospects of wide areas of therapeutic activity, in a way as an important medicinal source....
Medicinal plants have been in use for millenniums by human race as potential source of natural first aids against different ailments. But somewhere, the danger of adverse reactions haunted many pharmaceutical giants, leading to rejections of potential leads having side effects making them inappropriate for human consumption, causing them huge losses. Thus Natural route, as a source posses an advantage of lower rejections and higher productivity. Recent times have seen an increase in surge for pharmaceuticals setting up Nutraceutical Segment (S.B.U), focusing developing medicines for commercial use. Salvia officinalis Linn (Lamiaceae) perennial evergreen shrub with woody stems, grayish leaves and blue - purplish flowers contains following phytoconstituents Furfural, Tricyclene, α-Pinene, Camphene, Sabinene, β-Pinene, 3- Octane, Myrcene, 3-Octanol, α-Phellandrene, α-Terpinene, p-Cymene, Limonene, (Z)-β-Ocimene, (E)-β-Ocimene, γ-Terpinene, trans-Linalool oxide, Terpinolene, Linalool, cis-Thujone, trans-Thujone, Camphor, Borneol, Terpinen-4-ol, 3-Decanone, α-Terpineol, n-Dodecane, n-Decanol, Isobornyl acetate, Bornyl acetate, Carvacrol, n-Tridecane, α-Cubebene, Eugenol. The present review is an effort to concise a report on this medicinal plant and an up-to-date manifestation on pharmacological relevance explored so far....
Natural products have provided important therapeutic uses in several areas of medicine. The plant of Ageratum conyzoides were reported to possess good wound healing activity. The present study deals with microscopical analysis, preliminary phytochemical analysis and physicochemical parameters like Ash value, Loss on drying, Extractive values which could be a useful tool to prepare a monograph for proper identification of plants. Different solvents like petroleum ether, methanol+water and water were used for extraction and these extracts were subjected to preliminary phytochemical screening which reveals the presence of alkaloids, flavonoides, carbohydrates, tannins and phenols. The powdered plant was also subjected to fluorescence analysis using different chemicals....
Around the world, the use of medicinal plants for ailments had been in use for centuries. The advantage over other allopathic drugs, in terms of lower side effects, and more effective, provided enough motivation to carryout research for finding out potential medicinal activity for different ailments. One such plant of the genus Trichosanthes has been selected for the present review, it has found to be an native of Southern and Eastern Asia, Australia and islands of the western pacific popularly known as the pointed gourd, parval/parwal (Hindi), or potol (Assamese, Oriya or Bengali) and “Paror” in Marathi. It is grown widely in India, mainly in eastern parts namely, Orissa, Bengal, Assam, Bihar, and Uttar Pradesh. It is used as ingredients of soup, stew, curry, sweet or eaten with meat stuffing. Trichosanthes dioica (Roxb.) is dioecious, climber with perennial root stock. Brief description of T.dioica (Roxb.) is found in the Charaka samhita, Sushruta samhita. It has wide variety of medicinal actions, benefit for the pharmaceutical industry as a whole. It is good source of Carbohydrates, Vitamin A, and Vitamin C. During a period of few decades, many pharmacological activities in T. dioica (Roxb.), had been, explored. These researches highlighted the significance of the current plant, as a potential and effective, Antimicrobial, Ameliorative, Antidiabetic, Cholesterol lowering, Antinociceptive, Wound healing agent etc. The present review is an effort to sum up, an up-to-date pharmacological activities explored in it, plus giving an insight to explore, it further for the unexplored areas....
Dermatological disorders especially cuts, wounds and burns are ubiquitously cured by using medicimal plants from time immemorial. The objective of the study presented in this report was to screen the aqueous and ethanolic extracts of the bark of Emblica officinalis for its wound healing properties. The animals were randomized into four groups of control and treatment for both excision and incision wound model. Healing was assessed by the rate of wound contraction in every 3rd day of 15 days study period. On day 15 tissue was excised to determined the biochemical tissue marker of wound viz. Hydroxyproline, collagen and hexosamine. The treatment group showed a statistically significant reduction in the wound area as compared to control untreated group (P<0.05). An increment in the epithelization of the incision wound was monitored as considerable tensile strength was required for shearing the healed tissue in the test drug treated groups. Based on the enhanced wound contraction and histological evidence it can be suggested that the bark extract of Emblica officinalis may have therapeutic benefits of wound healing....
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